Part of the series “How to write a book from start to finish”

By J.E. Nickerson | Wise Thinkers Help Desk
As writers we often have to work with deadlines, whether we are mentally ready to write or struggling to clear mental cobwebs from our brain, while fighting fatigue. The next time you are looking for a villain to fight, you may want to look at the health issues we all face.
Sometimes, the greatest threat to your character’s journey comes from within — from a body that won’t cooperate, a memory that fades, or a mind that grows too tired to fight. As writers, we often chase big plot twists. But what if the real story lies in something quieter? Something personal?
In this article, we’ll explore how health itself — memory loss, exhaustion, pain — can become a hidden antagonist in your story. And how these struggles, often overlooked, can reveal the truest strength of your characters.
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đź§ 1. Memory Loss: When the Past Becomes a Stranger
In The Bourne Identity, Jason Bourne doesn’t just lose his memory — he loses control. The man he used to be might be a threat to the man he wants to become. That tension becomes the story.
Memento takes this even further. Leonard lives with short-term memory loss, forced to rely on notes and tattoos to track his past. But the real danger? His mind can’t distinguish truth from manipulation — even his own.
And in Unknown, Liam Neeson plays a man who wakes up from a coma only to find his entire life has been replaced. His wife doesn’t recognize him. Another man has taken his identity. The villain? It starts with the loss of memory — and grows into the terrifying possibility that the world has moved on without him.
đź’ˇ Writing Tip: Use memory loss to challenge identity. Who is your character without their past? What happens when they stop trusting themselves?
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🛏️ 2. Fatigue: The Villain That Slowly Wins
Some enemies don’t attack — they erode. Fatigue is one of them. It shows up day after day until your character can’t think clearly, can’t act, can’t hope.
In The Machinist, insomnia reduces Trevor to a ghost. He’s paranoid, emotionally wrecked, and unable to separate guilt from reality. His mind and body are collapsing at the same time — and that becomes the plot.
In a more grounded example, The Pursuit of Happyness shows how unrelenting exhaustion strips away joy, pride, and even dignity. The hero keeps going, but barely. And that “barely” is where the emotional stakes live.
💡 Writing Tip: Let exhaustion shape the arc. How does constant fatigue impact your character’s decisions, relationships, and resilience?
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đź’Ą 3. Pain, Anxiety, and Other Silent Enemies
Sometimes pain is physical. Sometimes it’s emotional. Sometimes it’s both — and it never leaves.
In Cake, Jennifer Aniston’s character lives with chronic pain after a traumatic loss. The pain isolates her, sharpens her bitterness, and becomes the lens through which she sees the world. The enemy isn’t another person. It’s the body that won’t let her heal.
💡 Writing Tip: Pain and anxiety don’t need to be explained — they just need to be felt. Let them color your scenes, even if they don’t control the plot.
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🎠Final Reflection:
Health struggles make powerful villains because they’re invisible. They don’t knock on the door. They live in the walls of your character’s world. And when written with care, they can say more about the human condition than any traditional antagonist ever could.
So if you’ve lived it — write it. If your body has ever betrayed you, or slowed you down when the world kept rushing past… know that you’re not alone. And neither is your reader. Your readers will be able to relate to characters who struggle with health issues because it humanizes your characters in a deeply personal way. Don’t be afraid to step out of the traditional vein of villains and experiment with health issues. You might find that you discovered a new way of connecting with readers who are struggling with their own physical challenges.
Learn how to create emotional ties between your characters that aren’t just physical. In the article Writing Emotional Closeness Between Characters we look at how to write meaningful, intimate moments that will make your readers feel connected to the characters.
📚 And if you’re new here, I’m J.E. Nickerson — faith based author and inspirational storyteller. You can check out my books here or follow me on YouTube for more inspiration and encouragement on this writing life.
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